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The Neutrophil Elastase Antibody (G-2): sc-55549 works very well for IHC with formalin fixed, paraffin-embedded tissue sections.

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This method is used for less temperature sensitive items such as lab ware and animal health products, bulky and/or heavy items Neutrophil Elastase (NE) is a serine protease that is expressed in bone marrow precursor cells, stored in peripheral blood granulocytes, and implicated in the progression of a variety of inflammatory diseases, including idiopathic pulmonary fibrosis, rheumatoid arthritis, adult respiratory distress syndrome and cystic fibrosis.

In neutrophils, Neutrophil Elastase contributes largely to the proteolysis of phagocytosed proteins, the migration of neutrophils and the remodeling of tissues following injury.

Neutrophil Elastase, which is also designated medullasin, is secreted into the extracellular matrix, where it is then capable of destroying connective tissue proteins, including elastin, proteoglycans and Type IV Collagens.

Neutrophil Elastase also mediates proteolysis by cleaving proteins that are associated with the complement system, such as antithrombin and Fibrinogen.

TRA-1-60 antigen was originally identified as a teratocarcinoma mucin-like antigen expressed on the surface of EC progenitor cells.